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  • Title: Differential effects of prazosin and rauwolsin on the release of prostaglandins I2 and E2 from the perfused mesenteric arterial bed of the rabbit following nerve stimulation.
    Author: Pipili E, Poyser NL.
    Journal: Prostaglandins; 1982 Mar; 23(3):299-309. PubMed ID: 7048423.
    Abstract:
    Sympathetic nerve stimulation of the perfused mesenteric arterial bed of the rabbit, in vitro, increases the secretion of prostaglandin (PG)I2 and PGE2. Prazosin (4.8 X 10(-6) M), an alpha 1 adrenergic receptor antagonist, inhibited this increase in release of PGI2 but not of PGE2 whereas rauwolsin (10(-7) M), and alpha 2 adrenergic receptor antagonist, inhibited the increase in release of PGE2 but not PGI2. Prazosin (10(-6) M) completely blocked the vasoconstrictor response to nerve stimulation, and to norepinephrine and phenylephrine administration, suggesting there to be little of an alpha 2 adrenergic receptor component in this response. It is concluded that the increase in PGI2 release allows the activation of alpha1 adrenergic receptors and is therefore post-junctional in origin, whereas the increase in PGE2 release following the activation of alpha 2 adrenergic receptors and may be pre- and/or post-junctional in origin.
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