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  • Title: The use of desmopressin (DDAVP) in nocturnal urinary frequency in the female.
    Author: Hilton P, Stanton SL.
    Journal: Br J Urol; 1982 Jun; 54(3):252-5. PubMed ID: 7049302.
    Abstract:
    Twenty-five patients complaining of nocturia completed a double-blind cross-over trial using desmopressin (DDAVP) and placebo. All had failed to respond to treatment with antispasmodic agents and evening fluid restriction. The drugs were given as a single intranasal dose on retiring. Nocturnal urinary frequency was reduced from a mean of 3.2 episodes to 2.6 with placebo and 1.9 with DDAVP (0.01 greater than P greater than 0.001). Diurnal urinary symptoms were not significantly affected and side effects were minimal. This drug seems to have a place in the treatment of nocturia, where more conventional therapies have failed.
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