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  • Title: Adrenergic modulation of gastric inhibitory polypeptide secretion in man.
    Author: Salera M, Ebert R, Giacomoni P, Pironi L, Venturi S, Corinaldesi R, Miglioli M, Barbara L.
    Journal: Dig Dis Sci; 1982 Sep; 27(9):794-800. PubMed ID: 7049625.
    Abstract:
    In order to examine the effect of adrenergic influences on gastric inhibitory polypeptide (GIP) secretion, a series of glucose tolerance tests was carried out in seven healthy volunteers during intravenous infusion of epinephrine (6 microgram/min), epinephrine plus phentolamine (5 mg stat + 0.5 mg/min), epinephrine plus propranolol (5 mg stat + 0.08 mg/min), and saline. No drug infusion modified fasting GIP levels. Alpha-adrenergic stimulation (epinephrine + propranolol) significantly reduced the GIP response (P less than 0.02) and completely inhibited the insulin response (P less than 0.005) to oral glucose, compared with control experiments. Epinephrine alone and epinephrine + phentolamine did not influence glucose-stimulated GIP. These results suggest the possibility that the adrenergic nervous system may have a role in the regulation of GIP secretion in man.
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