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  • Title: Iodinated [A1-N gamma-(4-azidophenylacetyl)-D-alpha, gamma-diaminobutyric acid]insulin: its preparation and properties.
    Author: Saunders DJ, Brandenburg D.
    Journal: Hoppe Seylers Z Physiol Chem; 1981 Sep; 362(9):1237-45. PubMed ID: 7049887.
    Abstract:
    The synthesis of a photo-sensitive analogue of pork insulin (A1-N gamma-(4-azidophenylacetyl)-D-alpha, gamma-diaminobutyric acid]insulin is reported. It could be shown that this analogue forms specific cross-links to binding proteins on irradiation with UV light. Furthermore, it was shown that the photo-label itself was not iodinated, nor did it influence the normal distribution of iodination. It can be concluded that this derivative bears all of the characteristics necessary for specifically labeling membrane-bound receptors.
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