These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Depression of learned thermoregulatory behavior by central injection of opioids in cats.
    Author: Clark WG, Bernardini GL.
    Journal: Pharmacol Biochem Behav; 1982 Jun; 16(6):983-8. PubMed ID: 7051050.
    Abstract:
    Third cerebral ventricular administration of morphine (20 microgram), pentazocine (1 mg) or the synthetic opioid peptides D-Ala2-Met-enkephalinamide (25 microgram) and D-Ala2-D-Leu5-enkephalin (10 microgram) decreased heat-reinforcement activity and either reduced or did not increase heat-escape activity of cats trained to control thermal stimuli through behavior. If the behavioral changes had been coupled to the primary effects of these opioids on thermoregulation, one would have expected an inverse relationship between changes in heat-reinforcement and heat-escape activity. Motor incapacitation appeared not to have contributed to the reduction in responding except briefly after pentazocine injection. The opioids may have distracted the animals or otherwise reduced their reaction to thermal stimuli until body temperature increased to a potentially dangerous level.
    [Abstract] [Full Text] [Related] [New Search]