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  • Title: Update of the University of California at San Francisco experience with donor-specific blood transfusions.
    Author: Salvatierra O, Iwaki Y, Vincenti F, Amend W, Terasaki P, Garovoy M, Duca R, Hopper S, Feduska N.
    Journal: Transplant Proc; 1982 Jun; 14(2):363-6. PubMed ID: 7051480.
    Abstract:
    Prospective pretreatment with deliberate DST has afforded MLC reactive related donor-recipient pairs enhanced opportunity for successful transplantation. The sensitization rate in patients receiving DST prior to primary transplantation was 30%, but this sensitization has been generally specific and narrow-those patients developing a positive DSXM do not appear to be jeopardized regarding later cadaver transplantation. Graft survival rates in 86 recipients of kidneys from their blood donors are 95% (1-year) and 93% (2-year). This graft survival rate appears to outweigh the minimal risk of possible unfavorable sensitization. Potentially unsuccessful transplants in immunologically disparate related donor-recipient pairs can be avoided, and the transplants actually performed have enhanced prospects of success.
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