These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of polyunsaturated fatty acids on the n-3 and n-6 series on platelet aggregation and platelet and aortic fatty acid composition in rabbits.
    Author: Vas Dias FW, Gibney MJ, Taylor TG.
    Journal: Atherosclerosis; 1982 Jun; 43(2-3):245-57. PubMed ID: 7052097.
    Abstract:
    Four groups of 6 New Zealand white rabbits were fed for 60 days on a commercial rabbit diet supplemented (60 g/kg) with 1 of 4 sources of fat: corn oil, linseed oil and fish oil, which respectively provided rich sources of linoleic acid (C18:2, n-6), alpha-linolenic acid (C18:3, n-3) and eicosapentaenoic acid (C20:5, n-3), and coconut oil, low in all polyunsaturated fatty acids (PUFA). Platelet-rich plasma was prepared and aggregation induced by ADP (final concentration 0.29-74.3 microM), collagen (2.5-20 micrograms/400 microliters, final concentration) and 2.5 U bovine thrombin, and recorded with a Peyton aggregometer. Platelet aggregation induced by both thrombin and collagen was significantly lower with either n-3 PUFA (fish or linseed oil) than with corn oil (n-6 PUFA) or the low PUFA coconut oil. ADP-induced platelet aggregation was significantly reduced only in animals fed fish-oil. Changes in platelet aggregation were accompanied by increased platelet lipid content of C20:5, n-3 and decreased content of C20:4, n-6, with little change in platelet total C20 fatty acids. Platelet levels of C20:5, n-3 were significantly increased with both the preformed C20:5, n-3 and its precursor C18:3, n-3 in the diet. However, aortic lipid accumulation of C20:5 only occurred with rabbits fed on fish oil. It was concluded that, for collagen and thrombin induced aggregation, C18:3, n-3 and C20:5, n-3 were equally antiaggregatory in rabbits. The implications of this in community nutrition programmes are discussed.
    [Abstract] [Full Text] [Related] [New Search]