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  • Title: Allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic or accelerated phase.
    Author: Champlin R, Ho W, Arenson E, Gale RP.
    Journal: Blood; 1982 Oct; 60(4):1038-41. PubMed ID: 7052161.
    Abstract:
    Eight patients with Ph1-positive chronic myelogenous leukemia (CML) in chronic or accelerated phase received high-dose cyclophosphamide, total body irradiation, and bone marrow transplantation from an HLA-identical sibling donor. All patients had prompt engraftment and achieved complete hematologic remission. Six patients remain alive and in continuous remission with a normal bone marrow karyotype 3-20+ mo posttransplant. One patient died from cytomegalovirus interstitial pneumonitis. Only one patient who was transplanted in accelerated phase relapsed 6.5 mo posttransplant and died in blast crisis. High-dose combined modality therapy is capable of producing sustained complete remissions in patients with CML treated during chronic or accelerated phase.
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