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  • Title: Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro.
    Author: Wyler DJ, Wahl SM, Wahl LM.
    Journal: Science; 1978 Oct 27; 202(4366):438-40. PubMed ID: 705337.
    Abstract:
    Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections.
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