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  • Title: Effects of irradiation on macrophagic response and transport of particles across the alveolar epithelium.
    Author: Adamson IY, Bowden DH.
    Journal: Am J Pathol; 1982 Jan; 106(1):40-6. PubMed ID: 7055210.
    Abstract:
    Macrophagic production and particulate penetration into the lung were studied in mice depleted of monocytes by whole body irradiation. Subsequent intratracheal instillation of 4 mg carbon resulted in a much smaller adaptive increase in the number of alveolar macrophages, as compared with nonirradiated animals. The decreased macrophagic output was associated with increased passage of free carbon across the Type 1 alveolar epithelium in increased accumulation of carbon in interstitial macrophages and hilar lymph nodes of irradiated mice. The results suggest that interference with the adaptive outpouring of alveolar macrophages following a particulate load facilitates the interaction of particles with macrophages within the pulmonary interstitium, where fibrogenic factors released in response to toxic agents would have a maximum effect.
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