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  • Title: Effects of neostigmine and pyridostigmine on serum cholinesterase activity.
    Author: Mirakhur RK, Lavery TD, Briggs LP, Clarke RS.
    Journal: Can Anaesth Soc J; 1982 Jan; 29(1):55-8. PubMed ID: 7055744.
    Abstract:
    Serum cholinesterase activities were measured from 270 minutes in patients following administration of neostigmine or pyridostigmine for the reversal of pancuronium block in groups of seven patients each. The enzyme activities were significantly depressed by neostigmine for four hours and by pyridostigmine throughout the whole period of study. Whereas the immediate effects of neostigmine were more intense, the effects of pyridostigmine beyond the first 30 minutes were more profound. The clinical relevance of these findings is discussed.
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