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  • Title: Unstable glycosylated hemoglobin in patients with diabetes mellitus.
    Author: Huisman W, Kuijken JP, Tan-Tjiong HL, Duurkoop EP, Leijnse B.
    Journal: Clin Chim Acta; 1982 Feb 05; 118(2-3):303-9. PubMed ID: 7055988.
    Abstract:
    Incubation of washed erythrocytes for 4 h at 37 degrees C in saline resulted in the disappearance of an unstable glycosylated fraction. In a reference group, its amount was very small, but its presence had a significant influence on the upper level of the reference range. In non-diabetic pregnant women, the unstable fraction was significantly higher than in the non-pregnant individuals, which resulted in a lower reference range for the stable HbA1. In diabetic patients, the average unstable HbA1 was about 10% of the "unincubated" level, with marked differences between individuals (0--30%), even in patients with a slightly elevated HbA1. Therefore it is important to determine the concentration of stable HbA1.
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