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  • Title: [Changes in the enzyme activity of the hydroxylating system of the rat liver endoplasmic reticulum in ischemia].
    Author: Voronov GG, Lukienko PI, Bushma MI.
    Journal: Farmakol Toksikol; 1982; 45(1):54-8. PubMed ID: 7056383.
    Abstract:
    Local disturbance of liver circulation for 40 minutes did not lead to any substantial changes in the hydroxylation system of microsomes of the ischemized area. 60-, 120- and 180-minute circulation distress causes a progressing decrease in amidopyrine and aniline metabolism, diminution of the content of cytochrome P-450 in the microsomes, and of the activity of NADP.H-ferricytochrome-c-reductase, NADP.H-neotetrazolium-reductase and NADP.H-oxidase. After 120-minute ischemia hydrophobic properties of the microsomal membranes were found to be decreased.
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