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  • Title: Maternally derived immunity to canine parvovirus infection: transfer, decline, and interference with vaccination.
    Author: Pollock RV, Carmichael LE.
    Journal: J Am Vet Med Assoc; 1982 Jan 01; 180(1):37-42. PubMed ID: 7056660.
    Abstract:
    Antibody to canine parvovirus (CPV) was transferred from an immune bitch to her pups through the placenta and colostrum. Colostral transfer accounted for approximately 90% of the maternally-derived CPV antibody. After suckling, pups and hemagglutination-inhibition titers that averaged 50% of their dam's titer. Maternally derived CPV antibody declined with a half-life of 9.7 days. Pups with hemagglutination-inhibition titers greater than or equal to 1:80 were immune to oronasal challenge with virulent CPV, but any detectable hemagglutination-inhibition antibody (titer greater than or equal to 1:10) interfered with active immunization by modified-liver feline panleukopenia virus, inactivated feline panleukopenia virus, or inactivated CPV vaccines.
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