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  • Title: Incidence of hypothyroidism occurring long after iodine-131 therapy for hyperthyroidism.
    Author: Holm LE, Lundell G, Israelsson A, Dahlqvist I.
    Journal: J Nucl Med; 1982 Feb; 23(2):103-7. PubMed ID: 7057248.
    Abstract:
    We have studied the long-term incidence of hypothyroidism in 4,473 formerly hyperthyroid patients given I-131 therapy between 1951 and 1975. The mean age at the first I-131 treatment was 56 yr. Six percent developed hypothyroidism within one year of therapy, and 72% within 26 yr. Prior antithyroid medication did not affect the incidence of hypothyroidism. Patients cured with one dose of I-131 had a lower cumulative long-term incidence of hypothyroidism than those requiring more than one dose.
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