These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cytotoxicity and mutagenicity of dinitrotoluenes in Chinese hamster ovary cells.
    Author: Abernethy DJ, Couch DB.
    Journal: Mutat Res; 1982 Jan; 103(1):53-9. PubMed ID: 7057784.
    Abstract:
    Technical grade dinitrotoluene (DNT), a mixture composed predominantly of 2,4- and 2,6-DNT but containing lesser amounts of 2,3-, 2,5-, 3,4- and 3,5-DNT, has been shown to be a hepatocarcinogen in rats, The mutagenicity of these compounds has been evaluated using the CHO/HGPRT system, a quantitative mammalian somatic cell mutational assay. Dinitrotoluenes were tested for their ability to induce mutation to 6-thioguanine (TG) resistance in the presence and absence of microsomal preparations (PMS) from rats pretreated with the mixed function oxidase inducer Aroclor 1254. A marked difference in cytotoxicity of the isomers was observed. However, neither technical grade DNT nor any of the purified isomers resulted in a significant increase in the TG-resistant fraction of surviving cells, with or without added PMS.
    [Abstract] [Full Text] [Related] [New Search]