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  • Title: Myoclonus and ocular oscillations induced by L-tryptophan.
    Author: Baloh RW, Dietz J, Spooner JW.
    Journal: Ann Neurol; 1982 Jan; 11(1):95-7. PubMed ID: 7059133.
    Abstract:
    A patient with chronic manic-depressive illness developed generalized myoclonus and spontaneous ocular oscillations after a single 2 gm dose of L-tryptophan. She had been pretreated with both a tricyclic antidepressant and a monoamine oxidase inhibitor. The involuntary movements gradually disappeared within 24 hours after the drugs were discontinued. Electrooculographic recording 7 hours after onset of the abnormal eye movements revealed square-wave jerks and hypometric voluntary saccades. Pursuit as well as optokinetic and vestibular slow phases were normal except for superimposition of the square-wave jerks. Repeat recording 24 hours later was entirely normal.
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