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  • Title: Complementary role of reticuloendothelial and hepatobiliary imaging agents in the assessment of liver disease.
    Author: Kim EE, Domstad PA, Choy YC, Coupal JJ, DeLand FH.
    Journal: Clin Nucl Med; 1982 Feb; 7(2):64-6. PubMed ID: 7060298.
    Abstract:
    The merit of concomitant hepatic imaging with Tc-99m-sulfur colloid (SC) and Tc-99m-HIDA was examined in 40 patients with abnormal liver function tests. The studies were performed sequentially within a 2 to 5 day interval with 5 mCi each of SC or HIDA. Routine static images in all cases, and dynamic studies with HIDA in 15 patients, were graded and compared with the liver function tests and clinical diagnoses. Of the 40 patients, the images with SC showed an abnormality in 22 while HIDA images were abnormal in 38. Thirteen of 21 patients with hepatocellular diseases showed an abnormality of the SC images, and 20 of the same 21 patients had abnormal HIDA images. Abnormal HIDA images were more closely related to abnormal liver function tests. These results suggest that alterations of hepatic function reflected by abnormal liver function tests are better demonstrated with hepatobiliary imaging agents than with reticuloendothelial imaging agents, while either type of imaging agents will detect focal anatomic lesions.
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