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  • Title: Metronidazole: an alternate therapy for antibiotic-associated colitis.
    Author: Cherry RD, Portnoy D, Jabbari M, Daly DS, Kinnear DG, Goresky CA.
    Journal: Gastroenterology; 1982 May; 82(5 Pt 1):849-51. PubMed ID: 7060906.
    Abstract:
    The results of treatment of 13 consecutive cases of antibiotic-associated pseudomembranous colitis with oral metronidazole are described. The diagnosis was made by typical sigmoidoscopic appearance with a confirming characteristic colonic biopsy specimen and/or stools positive for Clostridium difficile cytotoxin. All patients responded with the disappearance of diarrhea between 1 and 5 days. Two patients experienced relapse when the therapy was discontinued. Our experience with metronidazole shows that it is an effective treatment for antibiotic-associated pseudomembranous colitis. The response to metronidazole treatment compares favorably with that usually obtained with vancomycin.
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