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  • Title: Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine.
    Author: Krakowka S, Olsen RG, Axthelm MK, Rice J, Winters K.
    Journal: J Am Vet Med Assoc; 1982 Jan 15; 180(2):137-9. PubMed ID: 7061309.
    Abstract:
    Twelve gnotobiotic dogs from 2 litters were allotted to 3 groups. Group A dogs received a modified-live polyvalent (canine distemper, adenovirus type 2, and parainfluenza virus and Leptospira -canicola-icterohemorrhagiae bacterin) vaccine 3 days prior to oral inoculation with canine parvovirus (CPV). Group B dogs received CPV alone. Group C dogs received 1 dose of vaccine only. In none of the 9 CPV-inoculated dogs did clinical signs of CPV infection develop, although high serum antibody titers for CPV developed in all of them. However, in 2 of the 5 CPV-inoculated vaccinates, canine distemper virus encephalomyelitis subsequently developed. The results suggested that CPV exerts an immunomodulating effect on canine immune responses and may be responsible for vaccination failures in dogs.
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