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  • Title: [Pathogenetic study of complete and partial hydatidiform mole by HLA (author's transl)].
    Author: Honda J, Sato E, Ihara S, Munakata S, Sugawara N, Fukushima T.
    Journal: Nihon Sanka Fujinka Gakkai Zasshi; 1982 Jan; 34(1):83-8. PubMed ID: 7061896.
    Abstract:
    Twenty four complete and 15 partial moles, and the lymphocytes from the parents were analyzed for human lymphocyte antigen (HLA-A and HLA-B specificities), and karyotyping was done in each molar tissue by the direct method. Twelve of the 24 complete moles expressed homozygous A and/or B specificities identical to those of the father. No cases expressed A or B specificities derived from the maternal side. All had a 46, XX karyotype. On the other hand, in 6 of the 15 partial moles, the antigen specificities were heterozygous for A locus and 10 of the 15 expressed A and/or B specificities derived selectively from the maternal side. In chromosome studies, 8 of the 15 had a 69,XX karyotype, 5 had a 46,XX karyotype and 2 was impossible of analysis. These results show that complete moles are mostly androgenetic in origin but partial moles are not; that is, pathogenesis distinguishes complete from partial moles.
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