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  • Title: Failure of vasopressin to enhance memory in a passive avoidance task in rats.
    Author: Sahgal A, Keith AB, Wright C, Edwardson JA.
    Journal: Neurosci Lett; 1982 Jan 22; 28(1):87-92. PubMed ID: 7063145.
    Abstract:
    Several authors have suggested that the neurohypophysial hormone arginine-8-vasopressin (AVP) facilitates both the consolidation and the retrieval of memory. This conclusion has relied mainly on the finding that AVP increases the latency of re-entry into a box where shock has previously been encountered, that is, in a passive avoidance task. Our results do not support this interpretation. On the contrary, we found that post-trial, intraventricular (i.t.) administration of AVP (1 ng in 1 microliter) produced relatively short as well as long latencies (a bimodal effect), suggesting that the peptide acts on motivational processes, for example by increasing arousal.
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