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  • Title: Corticosterone: a critical factor in an opioid form of stress-induced analgesia.
    Author: MacLennan AJ, Drugan RC, Hyson RL, Maier SF, Madden J, Barchas JD.
    Journal: Science; 1982 Mar 19; 215(4539):1530-2. PubMed ID: 7063862.
    Abstract:
    The finding that some opioid-mediated forms of stress-induced analgesia are antagonized by hypophysectomy and dexamethasone has led to the suggestion that beta-endorphin, released from the pituitary, may mediate these analgesic reactions. "Long-term analgesia" (an opioid-mediated form of stress-induced analgesia), which is blocked by dexamethasone and hypophysectomy, was also blocked by adrenalectomy and reinstated with corticosterone therapy. Corticosterone is proposed to play a permissive role in long-term analgesia and to be a critical hormone mediating this phenomenon.
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