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  • Title: [Nonhistone proteins of the rat liver in malignant transformation by nitrosodiethylamine].
    Author: Seĭts IF, Glebov AV.
    Journal: Vopr Onkol; 1982; 28(1):42-6. PubMed ID: 7064395.
    Abstract:
    Qualitative and quantitative content of nonhistone chromosomal proteins (NHP) from normal and nitrosodiethylamine-transformed rat liver was studied. An increase in the protein/DNA ratio in tumor chromatin, as compared with that of normal tissue, was established. NHP were extracted from the chromatin with 0.4 N N2SO4 and fractionated with two-dimensional polyacrylamide gel electrophoresis. Coomassie staining revealed more than 80 fractions with molecular weights ranging 20-150 th. Some quantitative and qualitative differences in the patterns of NHP from normal and neoplastic tissues were observed. A conclusion is drawn that these differences may be related to structural and/or enzymatic components of NHP.
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