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  • Title: Influence of carotid sinus pressure on atrial receptors and renal blood flow.
    Author: Karim F, Mackay DU, Kappagoda CT.
    Journal: Am J Physiol; 1982 Feb; 242(2):H220-6. PubMed ID: 7065155.
    Abstract:
    Stimulation of the atrial receptors results in an increase in renal blood flow. The present investigation was undertaken to determine whether this response was modulated by the input from the baroceptors in the carotid sinus. The experiments were performed on dogs anesthetized with chloralose. The systemic arterial pressure was held constant. The carotid sinuses were perfused at 62 +/- 1.3, 95 +/- 2.7, and 145 +/- 8.3 mmHg. The atrial receptors were stimulated by distension of small balloons positioned at the left pulmonary vein-atrial junctions and the left atrial appendage. At a carotid sinus pressure of 62 +/- 1.3 mmHg, the blood flow increased from 182 +/- 8.5 to 199 +/- 8.9 ml . min-1 . 100 g-1 renal mass. At a carotid sinus pressure of 95 +/- 2.7 mmHg, the blood flow increased from 202 +/- 9.6 to 209 +/- 10.4 ml . min-1 . 100 g-1 renal mass. At a carotid sinus pressure of 145 +/- 8.3 mmHg, the blood flow increased from 237 +/- 13.0 to 239 +/- 12.5 ml . min-1 . 100 g-1 renal mass. The first two responses alone were statistically significant. The response at a carotid sinus pressure of 62 +/- 1.3 mmHg was abolished by cutting or cooling the cervical vagi to 8--10 degrees C. It is concluded that stimulation of the left atrial receptors produces a reflex increase in blood flow to the kidney, and this response is modulated by the input from the carotid sinus baroceptors.
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