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  • Title: [Lipid dependence of cytochrome P-450 activity in rat liver microsomes using lipid exchange proteins].
    Author: Diatlovitskaia EV, Petkova DKh, Lemenovskaia AF, Bergel'son LD.
    Journal: Biokhimiia; 1982 Feb; 47(2):216-20. PubMed ID: 7066425.
    Abstract:
    Modification of membrane lipid composition by lipid exchange proteins was used to study the lipid dependence of cytochrome P-450 activity in rat liver microsomes. The introduction of exogenous lysophosphatidylcholine into microsomal membranes decreased the capacity of cytochrome P-450 to demethylate dimethylaniline and dimethylaminoantipyrine and to hydroxylate aniline. A subsequent introduction of phosphatidylcholine resulted in an almost complete reactivation of the enzyme.
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