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  • Title: Evidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.
    Author: Tanooka H, Tanaka K.
    Journal: Cancer Res; 1982 May; 42(5):1856-8. PubMed ID: 7066900.
    Abstract:
    Fibrosarcomas produced by s.c. injection of 5 micrograms of 3-methylcholanthrene in Pgk-1a/Pgk-1b mice carrying X-chromosome inactivation mosaicism for the phosphoglycerate kinase (PGK-1) gene contained only one type of phosphoglycerate kinase in seven of eight cases (88%), as judged from its electrophoretic mobility, indicating the single-cell origin of the tumor.
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