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  • Title: Effects of 2-deoxy-D-glucose on plasma and adrenal concentrations of corticosterone and aldosterone in standard diet fed and potassium loaded rats.
    Author: Chevrier C, Hammiche N, Brudieux R.
    Journal: Horm Metab Res; 1982 Feb; 14(2):94-7. PubMed ID: 7068104.
    Abstract:
    The concentrations of corticosterone, aldosterone and electrolytes (Na+ and K+) were measured in the plasma and adrenal glands, following 2-deoxy-D-glucose (2-DG) treatment (2 injections of 50 mg/ml/100 g body weight) in standard diet fed and potassium loaded rats. In both regimens, 2-DG increased the concentrations of corticosterone mainly in the plasma (+144.8% and 229.5%) and to a lesser extent, in the adrenal glands (+50.9% and 62.5%). Conversely, 2-DG treatment was followed by a steep decline in plasma concentrations of aldosterone both in standard diet fed rats (-65.2%) and in potassium loaded rats (-83.9%), in spite of a marked increase in plasma (+233.3%) and in adrenal (+54.9%) levels of aldosterone after potassium loading; adrenal aldosterone content was essentially the same. Plasma and adrenal electrolytes concentrations and hematocrit varied very little after 2-DG treatment.
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