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  • Title: Biological activities of toxins A and B of Clostridium difficile.
    Author: Lyerly DM, Lockwood DE, Richardson SH, Wilkins TD.
    Journal: Infect Immun; 1982 Mar; 35(3):1147-50. PubMed ID: 7068215.
    Abstract:
    Examination of the biological activities of the two known toxins of Clostridium difficile revealed that one of the toxins (toxin A) elicited a hemorrhagic fluid response in rabbit intestinal loops and a positive fluid response in infant mice. The other toxin (toxin B) did not produce a significant fluid response in either model, although the toxin was more lethal in infant mice. Both toxins elicited erythematous and hemorrhagic skin reactions and increased vascular permeability in rabbit skin.
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