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  • Title: Functional compensatory changes after unilateral nephrectomy in rats. General and intrarenal hemodynamic alterations.
    Author: Lopez-Novoa JM, Ramos B, Martin-Oar JE, Hernando L.
    Journal: Ren Physiol; 1982; 5(2):76-84. PubMed ID: 7071410.
    Abstract:
    Cardiac output (CO), total peripheral resistance (TPR), renal blood flow (RBF), renal vascular resistance (RVR) and intrarenal blood flow distribution have been measured 48 h after unilateral (right) nephrectomy (UNX) and in sham-operated rats (SO). Glomerular filtration rate (GFR) and renal plasma flow (RPF) were determined using standard inulin and PAH clearances. Superficial single nephron GFR (SNGFR) was measured by free-flow micropuncture techniques. Extracellular fluid volume (ECV) and plasma volume (PV) were also determined. UNX rats showed increases of 17.4% in remnant kidney GFR and 34.5% in RPF. Filtration fraction was decreased to 0.27 +/- 0.01 (control value 0.31 +/- 0.01; p less than 0.0025). SNGFR was 45% higher in UNX rats and the ratio SNGFR/GFR increased by 28%. Cardiac output also increased (33.6 +/- 1.0 for UNX rats; 28.0 +/- 1.2 ml/min/100 g BW for SO rats; p less than 0.0025) accompanied by a corresponding fall (20%) in TPR. Left kidney RBF increased by 22%, whereas RVR decreased by 21%. Blood flow through individual glomeruli increased in the outer and inner cortex and was unchanged in the midcortex. In conclusion, 48 h after unilateral nephrectomy, rats showed a hyperdynamic circulatory state with increased CO and decreased TPR; this could be involved in the acute adaptive functional and renal changes reported after uninephrectomy.
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