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  • Title: The role if dopamine and norepinephrine uptake inhibition in mediating the central effects of d-amphetamine in vivo.
    Author: Feigenbaum JJ, Yanai J, Blass RB.
    Journal: Res Commun Chem Pathol Pharmacol; 1982 Feb; 35(2):333-5. PubMed ID: 7071417.
    Abstract:
    Male Sprague-Dawley rats were injected with 1.5 mg/kg d-amphetamine and later sacrificed at a time when the locomotor activity induced by this dose of d-amphetamine was maximal (60 minutes post injection). Subsequently, both cortical and striatal slices were measured for 3H-DA and 3H-NE uptake. It was found that in vivo, d-amphetamine does not preferentially inhibit the reuptake of DA or NE in either the striatum or cerebral cortex, suggesting that any selective effect on a specific catecholamine must result from a mechanism other than selective uptake inhibition.
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