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  • Title: Cadmium inhibition of in vitro hepatic oxidative drug metabolism in the rat: comparison between ionic cadmium and cadmium-thionein.
    Author: Roberts SA, Schnell RC.
    Journal: Res Commun Chem Pathol Pharmacol; 1982 Feb; 35(2):349-52. PubMed ID: 7071421.
    Abstract:
    The effectiveness of cadmium added in vitro in inhibiting the microsomal oxidative metabolism of ethylmorphine or aniline in rat hepatic microsomes was markedly decreased if the metal was added as cadmium-thionein when compared to ionic cadmium. These data are consistent with the hypothesis that cadmium thionein is less active biologically than ionic cadmium.
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