These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Inhibition of thyroidal iodine release by oestrogens in euthyroid subjects.
    Author: Zaninovich AA, Boado R, Ulloa E, Bromage NR, Matty AJ.
    Journal: Acta Endocrinol (Copenh); 1982 Mar; 99(3):386-92. PubMed ID: 7072447.
    Abstract:
    The effects of oestrogens on the release of thyroxine iodide (T4 I) and non-T4 I by the thyroid gland of 6 normal subjects and 3 thyrotrophin (TSH)-treated patients with hypopituitarism were assessed before, during and after treatment with 25 mg of Dienoestrol (Glaxo Lab.), orally, daily, during 8 days. Each subject received an iv injection of 150 microCi of 125I followed 6 days later by an iv injection of 75 microCi of [131I]T4. Blood samples and collections of urine were obtained every 12 h. From plasma and urinary (U) radioactivity, the ratio U[125I]/U[131I], U[125I]/PB[125I] and U[131I]/PB[131I] were obtained and served to calculate thyroidal iodine release and non-T4 I secretion by the thyroid gland. T4 I secretion was equivalent to T4 I disposal rate obtained by the semilogarithmic regression line of PB[131I]. In normal subjects, oestrogens decreased T4 I secretion from 491 +/- 57 (SD) nmol/day to 451 +/- 60 nmol (P less than 0.025), while in the same subjects serum TSH increased with oestrogens from 3.3 +/- 1.1 to 6.6 +/- 2.1 mU/l (P less than 0.01). The non-T4 I secretion had a mean of 585 +/- 307 nmol/day during control, 324 +/- 199 nmol during oestrogens (P less than 0.01) and 480 +/- 286 nmol oestrogens (P less than 0.05 vs oestrogens). In the TSH-treated patients oestrogens induced non-significant reductions in T4 I and non-T4 I secretion, although total iodine secretion decreased significantly (P less than 0.05). The data is consonant with a partial inhibition by oestrogens of thyroid gland release.
    [Abstract] [Full Text] [Related] [New Search]