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  • Title: Massive diphenhydramine overdose resulting in death.
    Author: Krenzelok EP, Anderson GM, Mirick M.
    Journal: Ann Emerg Med; 1982 Apr; 11(4):212-3. PubMed ID: 7073039.
    Abstract:
    Overdosage of diphenhydramine may result in the development of anticholinergic symptoms, seizures, and coma. A fatal outcome following a diphenhydramine overdose does not commonly occur. This report describes the largest documented overdosage of diphenhydramine (7.5 g) which resulted in the death of a 14-year-old girl. The patient initially developed seizures following by cardiac conduction and hemodynamic compromise resulting in death despite life support measures.
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