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  • Title: Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
    Author: Williams JC, Gusterson BA, Coombes RC.
    Journal: Br J Cancer; 1982 Apr; 45(4):588-97. PubMed ID: 7073949.
    Abstract:
    N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tumour induced with MNU in F344/N rats. Histologically, primary tumours and metastases in the lung and lymph nodes were similar. These systems may constitute useful models for the study of breast-cancer metastasis.
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