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  • Title: [Characterization of DNAse from rat brain].
    Author: Ivanov VA, Terpilovskaia ON, Tret'iak TM, Smirnova GN.
    Journal: Biokhimiia; 1982 Mar; 47(3):398-404. PubMed ID: 7074169.
    Abstract:
    Using gel filtration and ion exchange chromatography, a DNAse specific to a single-stranded DNA was isolated from the soluble fraction of rat brain nuclear proteins. The nuclear nuclease corresponds to alkaline DNAse obtained earlier from the intact brain. The enzyme is a Mg2+- or Mn2+-dependent exodeoxyribonuclease and hydrolyzes at the same rates the ss-DNAse from rat brain, calf thymus, E. coli and poly (dA). The major products of hydrolysis are nucleoside-5'-monophosphates. A possible role of the enzyme in reparation of neuronal DNA is discussed.
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