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  • Title: Glucocorticoid receptors, clinical characteristics, and implications for prognosis in chronic lymphocytic leukemia.
    Author: Simonsson B, Terenius L, Nilsson K.
    Journal: Cancer; 1982 Jun 15; 49(12):2493-6. PubMed ID: 7074566.
    Abstract:
    The cytoplasmic glucocorticoid-receptor (GR) content was analyzed in peripheral leukocytes from 52 nonselected patients with chronic lymphocytic leukemia (CLL). Forty-six patients had measurable GR levels. Six patients lacking measurable GR and seven of eight patients with a low GR content had inactive disease. However, there was no significant difference in average GR content between patients with progressive or nonprogressive disease. Twelve GR-positive patients were treated with prednisolone as the sole medication. Seven patients responded, some in several treatment sessions. There was no correlation between GR-content and clinical response. Thus, in our experience, cytoplasmic GR measurement has only limited predictive value.
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