These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of vasoactive agents on oxygen uptake in portal venous smooth muscle.
    Author: Ruiz RD, Cremer-Lacuara MG, Fiol de Cuneo M, Lacuara JL.
    Journal: Eur J Pharmacol; 1982 Mar 26; 78(4):395-402. PubMed ID: 7075675.
    Abstract:
    The studies concerned the effects of epinephrine, norepinephrine, phenylephrine, acetylcholine and K+ ions, in doses inducing maximal contraction on oxygen consumption of isolated rat portal veins. All the agonists tested stimulated the rate of O2 uptake, whereas high K+ did not. After specific blockade of alpha-adrenoceptors, the effects of epinephrine and norepinephrine on O2 consumption were not affected, whilst those of phenylephrine were abolished, and beta-adrenoceptor blockade suppressed the metabolic effect of epinephrine and norepinephrine. Acetylcholine was the agonist that most elevated O2 consumption; atropine blocked both contractile and metabolic effects of this drug. It appears that there is a clear dissociation between contractile and metabolic actions of some pharmacological agents, and a question is posed concerning phenylephrine and acetylcholine effects. Results with K+ suggest that different metabolic pathways might be involved in the activation and maintenance of drug-induced contraction in smooth muscle.
    [Abstract] [Full Text] [Related] [New Search]