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  • Title: A spontaneous rheumatoid arthritis-like disease in MRL/l mice.
    Author: Hang L, Theofilopoulos AN, Dixon FJ.
    Journal: J Exp Med; 1982 Jun 01; 155(6):1690-701. PubMed ID: 7077223.
    Abstract:
    MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with significant levels of IgMRF had synovitis and/or arthritis.
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