These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Des-acetyl MSH and gamma-MSH act as partial agonists to alpha-MSH on the Anolis melanophore.
    Author: McCormack AM, Carter RJ, Thody AJ, Shuster S.
    Journal: Peptides; 1982; 3(1):13-6. PubMed ID: 7079190.
    Abstract:
    The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of alpha-MSH, indicating that LPH37-58 is a full agonist of alpha-MSH. The lower potency peptides des-acetyl MSH and gamma-MSH reduced the effect of alpha-MSH and are, therefore, partial agonists of alpha-MSH. The action of MSH peptides in vivo may be modulated by interaction with agonists.
    [Abstract] [Full Text] [Related] [New Search]