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  • Title: Lifetime monoamine oxidase inhibition and sleep.
    Author: Mendelson WB, Cohen RM, Campbell IC, Murphy DL, Gillin JC, Wyatt RJ.
    Journal: Pharmacol Biochem Behav; 1982 Mar; 16(3):429-31. PubMed ID: 7079279.
    Abstract:
    The effects of clorgyline, a type A monoamine oxidase (MAO) inhibitor, on the sleep of the rat were examined after subacute and lifetime administration. When 2 mg/kg 24 hours were given for 60 hours, type A MAO was inhibited by 92% and a significant reduction in REM sleep time was noted. When fetal rats were exposed to maternal dosage of 1 mg/kg/24 hours and then received this dose from one to 6 weeks postnatally, type A MAO was inhibited by 99%, but there were no alterations in the EEG sleep stages. In summary, subacute administration of clorgyline resulted in decreases in both Type A MAO and REM sleep; during chronic administration in a developing animal, Type A MAO was again decreased, but there was no corresponding change in REM sleep.
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