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  • Title: Bombesin-like immunoreactivity in rat brain and gastrointestinal tract: influence of diet and starvation.
    Author: Soveny C, Hansky J.
    Journal: Regul Pept; 1982 Mar; 3(3-4):325-31. PubMed ID: 7079528.
    Abstract:
    A radioimmunoassay has been developed for the measurement of bombesin-like immunoreactivity (BLI) in mammalian tissues. BLI has been demonstrated in large amounts in the rat stomach and colon and in smaller amounts in the rat central nervous system. A 7-day high-carbohydrate diet leads to an increase in gastric and colonic BLI, a high protein diet to a decrease in fundic BLI. High fat and protein diets led to a decrease in midbrain BLI but other nervous tissues were not influenced by variation in diet. A 6-day fast increased antral, jejunal and ileal BLI; these increased levels fell on refeeding. These studies suggest a role for endogenous BLI in some aspects of gastric physiology, perhaps gastrin release.
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