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  • Title: Secretion of newly taken-up ascorbic acid by adrenomedullary chromaffin cells.
    Author: Daniels AJ, Dean G, Viveros OH, Diliberto EJ.
    Journal: Science; 1982 May 14; 216(4547):737-9. PubMed ID: 7079733.
    Abstract:
    Primary cultures of bovine adrenomedullary cells accumulate carbon-14-labeled ascorbic acid through a saturable and energy-dependent process. The newly taken-up ascorbate is released concomitantly with catecholamines upon stimulation of chromaffin cell secretion. The release of ascorbate is Ca2+-dependent and mediated through activation of nicotinic receptors. These results indicate that exogenous ascorbate taken up into chromaffin cells is incorporated in situ into a secretable compartment, probably the catecholamine-containing chromaffin vesicles.
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