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  • Title: [Regulatory mechanisms of oxygen transport function of hemoglobin in irradiated animals].
    Author: Sukhomlinov BF, Stoliar OB.
    Journal: Ukr Biokhim Zh (1978); 1982; 54(2):129-33. PubMed ID: 7080215.
    Abstract:
    The oxygen affinity of hemoglobin of both common and 2,3-diphosphoglycerate concentration-purified erythrocyte hemolysates, hemoglobin stability, 2,3-diphosphoglycerate concentration in erythrocytes, morphological blood content were studied in rabbits irradiated with X-rays in a dose of 0.155 C/kg. An increase in the oxygen affinity of common hemolysate hemoglobin at a higher 2,3-diphosphoglycerate concentration on the 1st, 4th day after irradiation and a decrease in the oxygen affinity of both common and purified hemolysate hemoglobin on the 18th-30th day after irradiation were observed. A conclusion is made that disturbance of the hemoglobin function control by 2,3-diphosphoglycerate in irradiated animals is determined by alteration of protein physicochemical properties.
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