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  • Title: [Characteristics of metabolism in fast-labelling nuclear RNA spleen cells of mice with Rauscher leukemia].
    Author: Smirnova IA, Kishinskaia EG.
    Journal: Ukr Biokhim Zh (1978); 1982; 54(2):159-62. PubMed ID: 7080218.
    Abstract:
    A component of quickly labelling D-RNA with a sedimentation coefficient of 35 S is revealed in spleen cell nuclei of mice infected with the leukemogenic Rauscher virus. The component is absent in healthy animals. It is labelled for 5 min of incubation with the label and under conditions of chase experiment disappears from the nucleus 2 h later differing from the rest of leukemic cell D-RNA in a higher metabolic activity. [3H] RNA with a sedimentation coefficient of 35 S is detected in cytoplasm of RNA synthetizing in leukemic cells under the effect of leukemogenic virus. It is the RNA of messenger type though it seems possible that a part of it remains in the nucleus and performs intranuclear functions.
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