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  • Title: The potentiating effect of clorgyline and pyrogallol on the blood pressure responses to norepinephrine.
    Author: Lai FM, Spector S.
    Journal: Arch Int Pharmacodyn Ther; 1978 Aug; 234(2):279-86. PubMed ID: 708154.
    Abstract:
    Intraventricular administration of norepinephrine (NE) into pentobarbital anesthetized rats elicits a pressor or a depressor effect depending on the dose injected: after a low dose, a depressor response is seen while after a high dose, a pressor response is observed. In the animal pretreated intraventricularly with clorgyline or pyrogallol, the hypotensive effect of a low dose of NE was reversed to a hypertensive effect, while the hypertensive effect of a high dose of NE was markedly potentiated. This result suggests that brain monoamine oxidase and catechol-o-methyltransferase can metabolize centrally released NE before it leaks into the peripheral circulation.
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