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  • Title: Enhancement of footshock-induced analgesia by spinal 5,7-dihydroxytryptamine lesions.
    Author: Hutson PH, Tricklebank MD, Curzon G.
    Journal: Brain Res; 1982 Apr 15; 237(2):367-72. PubMed ID: 7083000.
    Abstract:
    The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain 5-HT following injection of 5,7-dihydroxytryptamine into the spinal cord or raphe magnus. Injection of 5,7-DHT into the medial raphe which depleted brain but not spinal 5-HT was without effect.
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