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  • Title: Failure of spinal cord serotonin depletion to alter analgesia elicited from the periaqueductal gray.
    Author: Johannessen JN, Watkins LR, Carlton SM, Mayer DJ.
    Journal: Brain Res; 1982 Apr 15; 237(2):373-86. PubMed ID: 7083001.
    Abstract:
    The effects of spinal cord serotonin depletion or combined serotonin/norepinephrine depletion on analgesia elicited by electrical stimulation of, or morphine microinjection into, the periaqueductal gray, were tested. Spinal cord serotonin was depleted by intrathecal injection of 5,7-dihydroxytryptamine (5,7-DHT), preceded by systemic desipramine, while 5,7-DHT alone was used to deplete both norepinephrine and serotonin. Selective serotonin depletion had no effect on analgesia induced by either method at 24 h, 1 week, or 2 weeks after treatment. Depletion of both monoamines had no effect on stimulation produced analgesia 24 h and one week after treatment, but produced a slight attenuation 2 and 3 weeks after treatment. In contrast, depletion of both monoamines drastically attenuated morphine analgesia 24 h after treatment. The results are discussed in relation to multiple pain inhibitory pathways.
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