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  • Title: Apomorphine increases the activity of rat globus pallidus neurons.
    Author: Bergstrom DA, Bromley SD, Walters JR.
    Journal: Brain Res; 1982 Apr 22; 238(1):266-71. PubMed ID: 7083021.
    Abstract:
    Systemic administration of apomorphine, 0.08-1.0 mg/kg, caused a haloperidol-reversible increase in the unit activity of spontaneously firing neurons in the rat globus pallidus. Low doses of apomorphine (50, 20 micrograms/kg), which are thought to produce a net decrease in the stimulation of postsynaptic dopamine receptors, did not cause effects opposite to those observed with larger doses in 96% of the cells monitored. Blockade of dopamine receptors by administration of haloperidol did cause a moderate reduction in neuronal activity but only after administration of fairly high doses.
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