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  • Title: Phase II study of mitolactol and semustine combination chemotherapy for advanced malignant melanoma.
    Author: Creagan ET, Ahmann DL, Schutt AJ, Green SJ.
    Journal: Cancer Treat Rep; 1982 Jun; 66(6):1425-6. PubMed ID: 7083244.
    Abstract:
    Twenty-six patients with disseminated malignant melanoma received an oral regimen of mitolactol and semustine (methyl-CCNU). Sixteen patients had received prior systemic therapy, and 16 had visceral involvement. There were no objective regressions among ten patients receiving the drugs as initial systemic therapy. However, one of 16 patients having prior systemic treatment did have an objective response. Hematologic and gastrointestinal toxic effects were well-tolerated.
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